Well I am lucky I guess instead of feeling lonely 8 years ago a circle of friend got together and we launched our own interactive Networking / Chamber type organinzation. We have grown over those year and added resources and helped each other with support and finding creative ways to grow our companies. :-)
Many of us had tried local chamber or networking group and found that many did not get the trials and goal of those of us working from home. So we formed our own online support system and I have friend online I can connect live with in our chatrooms and IM and I can't do skype as I have a Satellte connection I am out in the country so had to me even more inventive working from home.
There are groups online that meet up in real time that you can connect to. SBRN Co-op is one of them. We host some Open Networking and Meet ups and Mixers.
Small Business Referral Network co-op Bring home business together to make the world better. http://smallbusinessreferralnetwork.com/benefits.html