First of all, I use Firefox ...
The background makes some pages impossible to read. There is absolutely no contrast between the text and the background on half the feedback form.
I think the quote request form needs to have some less specific fields on it, maybe just one big comments field. What if I am not sure where I want to go yet, and I just want you to call me to tell me the options?
On the specials page, your image floats over the top of the navigation button on the left side.
On the specials and feedback pages, I get a horizontal scrollbar, telling me that your page is wider than a 1024px screen. You need to suck that in a bit.
On the front page, the caption and the text on the second half is too close in font ... it blends and looks like it`s supposed to be the same paragraph.
A few of the images are weird and seem to have nothing to do with vacations.
All those little chicklets in the bottom right of the first page loaded really slow for me ... you may consider combining them into one faster-loading image.
Overall the site looks pretty cluttered in my opinion. You should take a look at
this site - it`s got a great clean look to it. While you don`t need something quite as complicated and expensive, you can get a site that is at least a step in that direction so your clients can navigate through it better. At the very least, I`m pretty sure someone has a quick template out there that is good for a travel-based theme. You should look around to see what your competition is doing in terms of their own website - does yours compete?
You also need to work on a good, strong, clear message. Why should I choose you to serve my travel needs?